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Page 3 of 11                                     Pediatric Transplantation



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   3           Introduction:
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   6           The first pediatric heart transplant was undertaken on December 6th 1967, just 3 days after the
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   8           first adult transplant, 50 years ago . The baby died five hours after transplant and Kantrowitz
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   10          subsequently published the case report . Despite a search of the medical literature and an
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   12          internet search, there is no scientific report of the first pediatric patient to survive. The internet
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   14          search however revealed a hospital website claiming that the first successful pediatric transplant
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   17          was 9  June 1984 . In the light of this information, we reviewed the International Society for
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   19          Heart & Lung Transplantation (ISHLT) Thoracic Organ Transplant Registry for outcomes from
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   21          the earliest patients transplanted. To our surprise, we discovered 30 pediatric patients entered
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   23          into the registry with the date of transplant prior to 1982 (the inception of the registry). This
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   25          previously unknown cohort was entered retrospectively into the registry, has not been previously
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   27          reported, and forms the basis of this report.
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   29                                   For Peer Review
   30          Methods:
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   33          The ISHLT Thoracic Organ Transplant Registry was interrogated on August 11  2017, for
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   35          pediatric heart transplant recipients (age <18 years) transplanted prior to 1  January 1982. The
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   37          de-identified data set was analyzed at Children’s Medical Dallas.
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   40          Clinical and demographic data is reported with descriptive statistics, continuous variables
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   42          reported as median, interquartile range (IQR), categorical variables reported as n, percent.
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   44          Patient survival was estimated by Kaplan-Meier curves with censoring at last known follow up if
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   46          lost-to follow-up or reported alive. Graft survival was compared to published data on graft
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   48          survival by center size with the chosen size 1-4 transplants per annum as there was only one
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   50          year (1981) prior to 1982 when more than 4 transplants were undertaken.
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   60                          The official publication of the International Pediatric Transplant Association
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