Page 5 - First Child
P. 5

Pediatric Transplantation                                   Page 4 of 11



   1
   2
   3           Results:
   4
   5
   6           Figure 1 details the year of primary transplant. Overall thirty children (24 male) had an age
   7
   8           range at time of primary transplant of 0-17 years (median 13; IQR 12-16) (Figure 2). Twenty-one
   9
   10          children were from North America; seven from Europe and two from the rest of world.
   11
   12          Diagnoses included cardiomyopathy (18); congenital heart disease (7) and not reported (5).
   13
   14          The follow-up was a median 2.63 years. (IQR 0.1-7.2).
   15
   16
   17          Patient Survival:
   18
   19
   20          Overall outcomes: Twenty patients (66.7%) were known to have died with their first graft and
   21
   22          two were lost to follow-up. Eight (26.7%) underwent retransplantation (two died, six were lost to
   23
   24          follow-up). Of the eight patients lost to follow-up their median follow-up time was 3.98 years
   25
   26          (range 0.16-15.5). The Kaplan-Meier patient survival curve is compared to subsequent eras in
   27
   28          Figure 3. The median (range) patient survival was 3.5 (0-15.5) years. The first patient to survive
   29                                   For Peer Review
   30
   31          more than one year (actually six years) was the second patient in 1968 and was 16 years old at
   32
   33          time of transplant. The youngest to survive more than one year was 13 years, transplanted in
   34
   35          1979. The youngest to survive at least 30 days was nine years old, transplanted in 1981.
   36
   37
   38          Graft Outcome & Retransplantation
   39
   40          Primary Graft Outcome: Median graft survival was 0.6 years (95% CI 0-4.2) and median one
   41
   42          year conditional graft survival was 4.6 years (CI 6.3-11.2). Graft survival is compared to a recent
   43
   44                                                                                      4
   45          ISHLT cohort from small volume centers (1-4 transplants per year) in Figure 4 . At the same
   46
   47          time point (0.6 years) median survival in the modern era was 87%.
   48
   49          Two patients were re-transplanted prior to 1982; one patient aged 17 years in 1974 (first graft
   50
   51
   52          lasted 57 days) and the second aged 14 years in 1976 (first graft lasted 153 days). An additional
   53
   54          six patients underwent retransplantation after 1981 with a median inter-transplant interval of 3.9
   55
   56          years (range 0.16 – 15.6 years).
   57
   58
   59
   60                          The official publication of the International Pediatric Transplant Association
   1   2   3   4   5   6   7   8   9   10